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CDC - CFS
Program Updates: 2002-2003
Currently, the CFS program focuses on detailed clinical studies of persons with
CFS and other fatiguing illnesses identified from defined populations and on
clinical modeling studies of CFS-like illness following various stresses....
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Feb 7, 2007
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CDC - CFS
Program Updates: 2004-2005
The CFS research program's specific aims are to 1) define the magnitude and
complexities of CFS as a public health problem; 2) define the natural history
and clinical parameters of CFS; 3) identify the pathophysiology, diagnostic
...
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Feb 7, 2007
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CDC - CFS
Program Updates: 2001
To do this, CDC will conduct a National Survey for CFS to estimate sex, age,
race/ethnic, socioeconomic-specific prevalence ratios of CFS and other fatiguing
illnesses. CDC has initiated a clinical study to further characterize th...
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Feb 7, 2007
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CDC - CFS Basic Facts
For more detailed information regarding the definition of CFS, please go to our
CFS Definition section. In addition to the eight primary defining symptoms of
CFS, a number of other symptoms have been reported by some CFS patients....
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Feb 6, 2007
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CDC - CFS Treatment
Options
Alternative therapies are often explored by CFS patients to relieve symptoms.
Health care professionals who are seeking information about helping CFS
patients develop effective coping strategies can find guidance on developing
an ...
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Feb 6, 2007
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CDC - CFS Meetings and
Workshops: May 1-3, 2000
During Session 2: Updated Concepts About CFS, Dr. Lloyd spoke on
post-infective fatigue as a model for CFS, Dr. Cleare spoke on using
neuroendocrinology and neurochemistry to define CFS, Dr. Evengard reviewed
knowledge concerning ...
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Feb 7, 2007
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CDC - CFS Screening
Natural killer (NK) cell assays: Some studies have reported a trend among CFS
patients to have reduced NK cell activity and/or reduced NK cell numbers.
Some studies, including the CDC's case-control study of CFS, have failed to
de...
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Feb 7, 2007
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CDC - CFS Clinical
Diagnosis
Diagnosing chronic fatigue syndrome (CFS) can be challenging for health care
professionals. A number of factors add to the complexity of making a CFS
diagnosis: 1) there's no diagnostic laboratory test or biomarker for CFS, 2)
fat...
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Feb 6, 2007
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CDC - CFS
Publications: Molecular Epidemiology
Successful utilization of genomics data to identify pharmacological targets
for complex illnesses such as chronic fatigue syndrome (CFS) will require
systematic integration of epidemiological, clinical, and laboratory data. The
se...
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Feb 7, 2007
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CDC - Diagnosing CFS
Diagnosing chronic fatigue syndrome (CFS) can be complicated by a number of
factors: 1) there's no diagnostic laboratory test or biomarker for CFS, 2)
fatigue and other symptoms of CFS are common to many illnesses, 3) CFS is an
in...
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Feb 6, 2007
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CDC - CFS Treatment
Options: Coping and Managing
While vigorous aerobic exercise is beneficial for many chronic illnesses, CFS
patients can't tolerate traditional exercise routines. Instead, CFS patients
must learn to pace activities and work with their health care
professionals...
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Feb 6, 2007
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CDC - CFS Meetings and
Workshops: October 13, 1999
Several consistent themes emerged from discussions at the meeting, including
recommendations regarding CFS program management issues, health information
and education, the CFS case definition, the possibility of changing the name
...
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Feb 7, 2007
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CDC - CFS Definition
The 1988 chronic fatigue syndrome (CFS) working case definition (Holmes, et
al) did not effectively distinguish CFS from other types of unexplained
fatigue. This publication addresses problems in applying the 1994 CFS
Research Cas...
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Feb 6, 2007
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CDC - CFS Revised Case
Definition (abridged version)
The 1988 chronic fatigue syndrome (CFS) working case definition (Holmes, et
al) did not effectively distinguish CFS from other types of unexplained
fatigue. Chronic fatigue in turn, is treated as a subset of prolonged
fatigue, whi...
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Feb 6, 2007
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CDC - CFS Possible Causes
Several investigators have reported lower numbers of natural killer cells or
decreased natural killer cell activity among CFS patients compared with
healthy controls, but others have found no differences between patients and
contr...
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Feb 6, 2007
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CDC - CFS
Factors influencing the diagnosis of chronic fatigue syndrome by primary
health care professionals.
Methods: We used data from a population-based study of CFS to identify
factors associated with receiving a CFS diagnosis. Results: We confirmed CFS
in 90 subjects; 14 (16%) had been previously diagnosed as having CFS.
Conclusion: ...
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Feb 7, 2007
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CDC - CFS
Chronic fatigue syndromea clinically empirical approach to its
definition and study
This reflects, in part, the lack of standardized reproducible diagnostic
criteria for CFS, and in 2003 an International CFS Study Group published
recommendations concerning application of the case definition. Two hundred
twenty-se...
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Feb 7, 2007
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CDC - Symptoms of CFS
The fatigue of CFS is accompanied by characteristic symptoms lasting at least
six months. While symptoms vary from person to person in number, type and
severity, all CFS patients are functionally impaired to some degree. Some
pati...
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Feb 7, 2007
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CDC - CFS Risk
factors for CFS: a case control study.
Several factors were found to be preferentially associated with CFS cases,
but none that could be used to effectively distinguish CFS cases from
controls. Patients: Twenty-five CFS patients identified from the Centers for
Disease ...
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Feb 7, 2007
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CDC - CFS
Surveillance for chronic fatigue syndrome - four U.S. cities, September 1989 through
August 1993.
Problem/Condition: Although chronic fatigue syndrome (CFS) has been
recognized as a cause of morbidity in the United States, the etiology of CFS
is unknown. Reporting Period Covered: This report summarizes CFS surveillance
data co...
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Feb 7, 2007
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CDC - CFS
Publications: Economic Impact
CDC studies of chronic fatigue syndrome (CFS) in the general population of
Wichita, Kansas, have allowed us to estimate the economic impact of this
syndrome. Methods: We used microsimulation methods to analyze data from a
surveill...
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Feb 7, 2007
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CDC - CFS A
population-based study of the clinical course of chronic fatigue syndrome.
We evaluated changes in CFS classification (partial or total remission,
alternative medical or psychiatric diagnoses), CFS case-defining criteria,
wellness scores, hours of activities and sleep, and treatments used to reduce
fatig...
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Feb 7, 2007
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CDC - CFS
Chronic Fatigue Syndrome Progression and Self-defined Recovery: Evidence from
the CDC Surveillance System.
Objective: To examine the presence of symptoms associated with chronic fatigue
syndrome (CFS) over the course of the illness and determine the probability
of self-defined recovery by duration of illness. Measurements: Presence of
...
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Feb 7, 2007
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CDC - CFS
Utility of the blood for gene expression profiling and biomarker discovery in
chronic fatigue syndrome.
Gene expression profiling examines the activity (transcription) of genes by
analyzing cell's messenger RNA (mRNA). This paper is the first use of gene
expression profiling as a biomarker to distinguish persons with CFS from
health...
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Feb 7, 2007
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CDC - CFS
Prevalence and incidence of chronic fatigue syndrome in Wichita, Kansas.
Methods: We conducted a random digit-dialing survey and clinical examination
to estimate the prevalence of CFS in the general population of Wichita,
Kansas, and a 1-year follow-up telephone interview and clinical examination
to es...
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Feb 7, 2007
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CDC - CFS
Identification of ambiguities in the 1994 chronic fatigue syndrome research
case definition and recommendations for resolution.
An International Chronic Fatigue Syndrome Study Group, convened by CDC, has
published the first international consensus paper addressing problems in
applying the 1994 CFS Research Case Definition and recommending an approach
to gu...
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Feb 7, 2007
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CDC - CFS Integration
of gene expression, clinical, and epidemiologic data to characterize chronic
fatigue syndromes.
Integration of gene expression, clinical, and epidemiologic data to
characterize chronic fatigue syndromes. This study was an extension of
earlier work by the CDC CFS Research Group, which showed that peripheral
blood cell gene ex...
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Feb 7, 2007
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CDC - CFS Meetings and
Workshops: May 20-23, 2001
During May 20-23, 2001, the Centers for Disease Control and Prevention (CDC)
sponsored a workshop on Issues Related to the Chronic Fatigue Syndrome (CFS)
Research Case Definition . There was agreement that revisions to the CFS
res...
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Feb 7, 2007
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CDC - CFS
Evaluation of autoantibodies to common and neuronal cell antigens in chronic
fatigue syndrome.
People with chronic fatigue syndrome (CFS) suffer from multiple symptoms
including fatigue, impaired memory and concentration, unrefreshing sleep and
musculoskeletal pain. The exact causes of CFS are not known, but the symptom
com...
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Feb 7, 2007
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CDC - CFS
Complement activation in a model of chronic fatigue syndrome.
One such symptom trigger, also part of the CFS definition, is physical
exertion; the other trigger known to reproduce symptoms of CFS is exposure to
allergens. We hypothesized that challenge with either exercise or allergens
would...
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Feb 7, 2007
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CDC - CFS Meetings and
Workshops: Banbury
The CDC CFS Research Program sponsored a workshop, Integrating Disparate Data
to Simulate Lymphocyte Function, at the Banbury Center, Cold Spring Harbor Laboratory,
on September 19-22, 2004. We chose to focus the workshop on lymph...
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Feb 7, 2007
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CDC - CFS: Diagnostic
Symptoms
A CFS diagnosis should be considered in patients who present with six months
or more of unexplained fatigue accompanied by other characteristic symptoms.
In addition to the eight primary defining symptoms of CFS, a number of
other...
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Feb 6, 2007
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CDC - CFS
Medication use by persons with chronic fatigue syndrome: results of a
randomized telephone survey in Wichita Kansas.
Persons with CFS utilize a variety of prescribed and non-prescribed
medications and supplements to relieve their symptoms and regain pre-illness
activity levels. Remarkably, there are few reports of medication use by
persons with ...
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Feb 7, 2007
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CDC - CFS
Psychometric properties of the CDC symptom inventory for the assessment of
chronic fatigue syndrome.
Evaluation included a physical examination, a standardized psychiatric
interview, three previously validated self-report questionnaires measuring
fatigue and illness impact (Medical Outcomes Survey Short-Form-36 [SF-36],
Multidime...
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Feb 7, 2007
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CDC - CFS
Management strategies for chronic fatigue syndrome.
This publication offers a detailed guideline to physicians for the diagnosis
and treatment of CFS patients. Chronic fatigue syndrome (CFS) is
characterized by severe, persistent fatigue and self-perceived symptoms
(defined as symp...
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Feb 7, 2007
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CDC - CFS
Chronic fatigue syndrome and other fatiguing illnesses in adolescents: A
population-based study.
Purpose: To estimate the prevalence of chronic fatigue syndrome (CFS) and
describe characteristics of other fatiguing illnesses in adolescents (ages 12
through 17 years). Following clinical evaluation they were classified as CFS
o...
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Feb 7, 2007
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CDC - CFS
Analysis of 16S rDNA sequences and circulating cell-free DNA concentration
from plasma of a chronic fatigue syndrome and non fatigued subjects.
Analysis of 16S rDNA sequences and circulating cell-free DNA concentration
from plasma of a chronic fatigue syndrome and non fatigued subjects. Plasma
DNA from 34 CFS and 55 non-fatigued subjects was assessed to determine plasma
D...
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Feb 7, 2007
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CDC - CFS
Physical, behavioral, and psychological risk factors for chronic fatigue
syndrome: A central role for stress?
In spite of the distinct epidemiologic features of chronic fatigue syndrome,
its cause remains unknown and no risk factors for the illness have been
identified. In order to better characterize CFS, we conducted a case-control
stud...
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Feb 7, 2007
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CDC - CFS
Defining the chronic fatigue syndrome
The author points out the problems associated with interpreting and comparing
early CFS research studies because no uniform definition was available. The
recently published working definition of the chronic fatigue syndrome (CFS)
...
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Feb 7, 2007
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CDC - CFS
Publications: Adolescents
This section contains a report covering issues specific to chronic fatigue
syndrome (CFS) in adolescents. Using information from three studies of
fatiguing illness conducted by CDC that included information about
adolescents, an a...
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Feb 7, 2007
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CDC - CFS Differential
display PCR of peripheral blood for biomarker discovery in chronic fatigue
syndrome.
The CDC CFS Molecular Epidemiology effort is using microarray gene expression
profiling as a tool to search for biomarkers. We have shown that microarray
gene expression profiling shows differences between CFS cases and controls
a...
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Feb 7, 2007
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CDC - CFS
Assessment of a retroviral sequence and other possible risk factors for the
chronic fatigue syndrome in adults.
This study of the reported HTLV-II-like marker for CFS was conducted on 21
metropolitan Atlanta cases, 21 controls from among CDC employees, and 42
neighborhood controls matched with patients by age, race, and sex. Objective:
To a...
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Feb 7, 2007
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CDC - CFS Who's at Risk
Researchers continue to explore possible causes and risk factors for CFS. CFS
occurs four times more frequently in women than in men, although people of either
gender can develop the disease. The illness occurs most often in peopl...
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Feb 6, 2007
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CDC - CFS Factor
analysis of symptoms among subjects with unexplained chronic fatigue: what
can we learn about chronic fatigue syndrome?
Factor analysis of symptoms among subjects with unexplained chronic fatigue:
what can we learn about chronic fatigue syndrome? CFS symptomatology is a
multidimensional phenomenon overlapping with other unexplained fatiguing
syndro...
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Feb 7, 2007
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CDC - CFS GBV-C ?
a virus without a disease: we cannot give it chronic fatigue syndrome
Jones JF, Reeves WC GBV-C -w a virus without a disease: we cannot give it
chronic fatigue syndrome BMC Infectious Diseases 5:78, 2005. Although a
single infectious agent does not cause chronic fatigue syndrome ( CFS) and
the epide...
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Feb 7, 2007
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CDC - CFS Risk Groups
Researchers continue to explore possible causes, risk factors and triggering
factors for CFS. CFS occurs up to four times more frequently in women than in
men, although people of either gender can develop the disease. The illness
...
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Feb 6, 2007
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CDC - CFS
Regional distribution of fatiguing illnesses in the United States: a pilot
study.
Overall, 12% of the studied population suffered from fatigue lasting for at
least 6 months (chronic fatigue), and 1% described a "CFS-like"
illness, which needed medical evaluation for confirmation of the CFS
diagnosis. Background...
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Feb 7, 2007
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CDC - CFS: Support Groups
- Outside US
To be listed on our web page as a patient support contact, you will need to
complete and mail a request form. Citation of organizations and individuals
involved in patient support for CFS is made here as a convenience to patients
...
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Feb 7, 2007
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CDC - CFS Chronic
fatigue syndrome: what role does the autonomic nervous system play in the
pathophysiology of this complex illness?
Chronic fatigue syndrome: what role does the autonomic nervous system play in
the pathophysiology of this complex illness? Gerrity TR, Bates J, Bell DS,
Chrousos G, Furst G, Hedrick T, Hurwitz B, Kula RW, Levine SM, Moore RC,
Scho...
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Feb 7, 2007
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CDC - CFS Awareness
Campaign: Radio 60 Second PSA
As the nations health protection agency, CDC has been researching CFS for
years and weve really learned a lot. I hope the information presented here
and available on CDC web site will encourage you to learn more about CFS to
hel...
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Feb 7, 2007
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