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Research Interests
Dr. Pall has long-term interests in biological regulatory mechanisms. His
current research is focussed on a theory he has developed on the cause
(etiology) of chronic fatigue syndrome and the overlapping and related
conditions of multiple chemical sensitivity, fibromyalgia, and posttraumatic stress
disorder. According to this theory, each of these is initiated by stresses
that induce increased levels of nitric oxide and its oxidant product
peroxynitrite, followed by a biochemical vicious cycle mechanism associated
with chronic elevation of these two compounds. Symptoms of these conditions
are produced by both nitric oxide and peroxynitrite and treatment should
focus on downregulating this vicious cycle mechanism. Vitamin B-12 injections
commonly used to treat these conditions are proposed to act through the
action of one form of B-12 (hydroxocobalamin) which is a potent nitric oxide
scavenger. Dozens of biochemical and physiological observations provide
support for this theory. The most puzzling features of these conditions are
explained by this novel theory.
Chronic Fatigue Syndrome
Fibromyalgia, Excessive Nitric
Oxide/Peroxynitrite and Excessive NMDA Activity
Multiple Chemical Sensitivity
Publications
Pall ML. Elevated, sustained peroxynitrite levels as the cause of chronic
fatigue syndrome. Medical Hypotheses 2000;54:115-125.
Pall ML. Elevated peroxynitrite as the cause of chronic fatigue syndrome:
Other inducers and mechanisms of symptom generation. Journal of Chronic
Fatigue Syndrome 2000;7(4):45-58.
Pall ML. Cobalamin used in chronic fatigue syndrome therapy is a nitric oxide
scavenger. Journal of Chronic Fatigue Syndrome, 2001;8(2):39-44.
Pall ML, Satterlee JD. Elevated nitric oxide/peroxynitrite mechanism for the
common etiology of multiple chemical sensitivity, chronic fatigue syndrome
and posttraumatic stress disorder. Annals of the New York Academy of Science
2001;933:323-329.
Pall ML. Common etiology of posttraumatic stress disorder, fibromyalgia,
chronic fatigue syndrome and multiple chemical sensitivity via elevated
nitric oxide/peroxynitrite, Medical Hypotheses, 2001;57:139-145.
Pall ML. Levels of the nitric oxide synthase product citrulline are elevated
in sera of chronic fatigue syndrome patients. J Chronic Fatigue Syndr
2002;10(3/4):37-41.
Pall ML. NMDA sensitization and stimulation by peroxynitrite, nitric oxide
and organic solvents as the mechanism of chemical sensitivity in multiple
chemical sensitivity. FASEB J 2002;16:1407-1417.
Pall ML. Chronic fatigue syndrome/myalgic encephalitis. Br J Gen Pract
2002;52:762.
Smirnova IV, Pall ML. Elevated levels of protein carbonyls in sera of chronic
fatigue syndrome patients. Mol Cell Biochem, in press.
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