Deze abstract gaat over onderzoek naar abnormaliteiten
bij COI & POTS.
COI = Chronic orthostatic intolerance
POTS = postural tachycardia syndrome (POTS
Postural orthostatic tachycardia syndrome
(POTS, also postural tachycardia syndrome) is a condition
of dysautonomia,[1]
more specifically orthostatic intolerance,
in which a change from the supine position
to an upright position causes an abnormally large increase in heart
rate, called tachycardia.
Several studies show a decrease in cerebral blood flow with systolic and
diastolic cerebral blood flow
(CBF) velocity decreased 44% and 60%, respectively.[2]
Patients with POTS have problems maintaining homeostasis when changing
position, i.e. moving from one chair to another or reaching above their
heads. Many patients also experience symptoms when stationary or even
while lying down.
Increasing orthostatic stress impairs neurocognitive functioning in
Chronic Fatigue Syndrome with Postural Tachycardia Syndrome.Symptoms
present in various degrees of severity depending on the patient. POTS
can be severely debilitating. Some patients are unable to attend school
or work, and especially severe cases can completely incapacitate the
patient.
Studies have indicated a high degree of association between POTS and CFS.
"POTS is sometimes found in Fibromyalgia," and "POTS may share a common
pathophysiology with CFS." POTS is a disorder
characterized by a pulse/heart rate that is too fast when the patient stands.
Our preliminary data have shown that POTS physiology
underlies orthostatic intolerance in the large majority of adolescents with
the
chronic fatigue syndrome
Researchers supported by the National Institute of Arthritis and Musculoskeletal
and Skin Diseases have discovered that an enzyme called calcium/calmodulin-dependent
protein kinase (CaMK) is a major player in activating "slow-twitch" muscles
Chronic Fatigue Syndrome/ME and Fibromyalgiaplus
Associated Syndromes. Evidence for their organic basis: A summary
of the suggested underlying pathophysiologies and treatment approaches
The authors present for the first time evidence for enteroviral persistence
in humans based on sequence comparison of serial PCR products from the 5'
non-translated region (NTR).
