The research in my laboratory focuses on the elucidation of the role of
the 2',5'-oliogadenylate [2-5A] synthetase/RNase L and p68 kinase [PKR]
pathways
Photoaffinity labeling and immunoprecipitation studies of extracts of
peripheral blood mononuclear cells have demonstrated the presence of a
novel, low molecular weight (37-kDa) form of 2-5A-dependent RNase L in a
sub group of patients with chronic fatigue syndrome (CFS)